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Hepatitis C: An Introduction for Primary Care Providers

Prevalence and Management of Chronic Hepatitis C Virus Infection in Women.
Beste LA, Bondurant HC, Ioannou GN.
Med Clin North Am. 2015 May;99(3):575-86. doi: 10.1016/j.mcna.2015.01.009. Epub 2015 Feb 28.
PMID: 25841601

Hepatitis C virus seroprevalence in the general female population from 8 countries.
Quesada P, Whitby D, Benavente Y, Miley W, Labo N, Chichareon S, Trong N, Shin HR, Anh PT, Thomas J, Matos E, Herrero R, Muñoz N, Molano M, Franceschi S, de Sanjosé S.
J Clin Virol. 2015 Jul;68:89-93. doi: 10.1016/j.jcv.2015.05.005. Epub 2015 May 12.
PMID: 26071344

Suboptimal Surveillance for and Knowledge of Hepatocellular Carcinoma Among Primary Care Providers.
McGowan CE, Edwards TP, Luong MU, Hayashi PH.
Clin Gastroenterol Hepatol. 2015 Apr;13(4):799-804. doi: 10.1016/j.cgh.2014.07.056. Epub 2014 Aug 10.
PMID: 25117773

Screening and Diagnosis of Hepatitis C

Evaluation of viral load in saliva from patients with chronic hepatitis C infection.
Xavier Santos RL, de Deus DM, de Almeida Lopes EP, Duarte Coêlho MR, de Castro JF.
J Infect Public Health. 2015 Sep-Oct;8(5):474-80. doi: 10.1016/j.jiph.2015.04.025. Epub 2015 Jun 2.
PMID: 26044945

On-chip purification and detection of hepatitis C virus RNA from human plasma.
Vaghi V, Potrich C, Pasquardini L, Lunelli L, Vanzetti L, Ebranati E, Lai A, Zehender G, Mombello D, Cocuzza M, Pirri CF, Pederzolli C.
Biophys Chem. 2015 Jun 11. pii: S0301-4622(15)30009-0. doi: 10.1016/j.bpc.2015.06.005. [Epub ahead of print].
PMID: 26091724

The effect of introducing point-of-care or dried blood spot analysis on the uptake of hepatitis C virus testing in high-risk populations: A systematic review of the literature.
Coats JT, Dillon JF.
Int J Drug Policy. 2015 Jun 4. pii: S0955-3959(15)00134-6. doi: 10.1016/j.drugpo.2015.05.001. [Epub ahead of print] PMID: 26118799

Hepatitis C Treatment and Management in Real World Settings

Effect of Gender on the Response to Hepatitis C Treatment in an Inner-City Population.
Simoes P, Asaad A, Abed J, Engelson ES, Kotler DP.
Womens Health Issues. 2015 May-Jun;25(3):289-93. doi: 10.1016/j.whi.2015.02.008.
PMID: 25965157

Injecting risk behaviours following treatment for hepatitis C virus infection among people who inject drugs: The Australian Trial in Acute Hepatitis C.
Alavi M, Spelman T, Matthews GV, Haber PS, Day C, van Beek I, Walsh N, Yeung B, Bruneau J, Petoumenos K, Dolan K, Kaldor JM, Dore GJ, Hellard M, Grebely J; ATAHC Study Group.
Int J Drug Policy. 2015 May 21. pii: S0955-3959(15)00136-X. doi: 10.1016/j.drugpo.2015.05.003. [Epub ahead of print] PMID: 26115881

The effect of social functioning and living arrangement on treatment intent, specialist assessment and treatment uptake for hepatitis C virus infection among people with a history of injecting drug use: The ETHOS study.
Fortier E, Alavi M, Micallef M, Dunlop AJ, Balcomb AC, Day CA, Treloar C, Bath N, Haber PS, Dore GJ, Bruneau J, Grebely J; ETHOS Study Group.
Int J Drug Policy. 2015 Jun 11. pii: S0955-3959(15)00181-4. doi: 10.1016/j.drugpo.2015.06.001. [Epub ahead of print] PMID: 26145482

Free HCV Peer-Reviewed PDF Bonanza!!! New peer-reviewed, full-text articles in the section of the Resource Center focused toward Hepatologists, Gastroenterologists & Infectious Disease Specialists

Please visit the American Journal of Medicine Hepatitis C Resource Center (hepcresource.amjmed.com) to access the free full-text articles.

Hepatitis C: Clinical Scenarios and Therapeutic Overview

Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum.
Meyer JP, Moghimi Y, Marcus R, Lim JK, Litwin AH, Altice FL.
Int J Drug Policy. 2015 May 17. pii: S0955-3959(15)00135-8. doi: 10.1016/j.drugpo.2015.05.002. [Epub ahead of print] PMID: 26077144

Gender differences in planning ability and hepatitis C virus among people who inject drugs.
Scheidell JD, Khan MR, Clifford LM, Dunne EM, Keen LD 2nd, Latimer WW.
Addict Behav. 2015 Aug;47:33-7. doi: 10.1016/j.addbeh.2015.03.019. Epub 2015 Mar 26.
PMID: 25863005

Modeling the effect of HIV coinfection on clearance and sustained virologic response during treatment for hepatitis C virus.
Birgera R, Kouyosb R, Dushoff J, Grenfella B.
Epidemics. 2015;12:1-10.

Genetics, Polymorphisms, and Treatment Resistance

Genetic barrier and variant fitness in hepatitis C as critical parameters for drug resistance development.
Welsch C.
Drug Discov Today Technol. 2014 Mar;11:19-25. doi: 10.1016/j.ddtec.2013.12.003.
PMID: 24847649

Molecular principles behind Boceprevir resistance due to mutations in hepatitis C NS3/4A protease.
Nagpal N, Goyal S, Wahi D, Jain R, Jamal S, Singh A, Rana P, Grover A.
Gene. 2015 Oct 1;570(1):115-21. doi: 10.1016/j.gene.2015.06.008. Epub 2015 Jun 6.
PMID: 26055089

Telaprevir or boceprevir based therapy for chronic hepatitis C infection: Development of resistance-associated variants in treatment failure.
Macartney MJ, Irish D, Bridge SH, Garcia-Diaz A, Booth CL, McCormick AL, Labbett W, Smith C, Velazquez C, Tanwar S, Trembling P, Jacobs M, Dusheiko G, Rosenberg W, Haque T.
Antiviral Res. 2014 May;105:112-7. doi: 10.1016/j.antiviral.2014.02.019. Epub 2014 Mar 1.
PMID: 24594347

Hepatitis C Clinical Trials

Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C.
Khalaf N, White D, Kanwal F, Ramsey D, Mittal S, Tavakoli-Tabasi S, Kuzniarek J, El-Serag HB.
Clin Gastroenterol Hepatol. 2015 Aug;13(8):1521-1531.e3. doi: 10.1016/j.cgh.2015.01.030. Epub 2015 Mar 14.
PMID: 25777972

Ledipasvir and sofosbuvir for hepatitis C genotype 4: a proof-of-concept, single-centre, open-label phase 2a cohort study.
Kohli A, Kapoor R, Sims Z, Nelson A, Sidharthan S, Lam B, Silk R, Kotb C, Gross C, Teferi G, Sugarman K, Pang PS, Osinusi A, Polis MA, Rustgi V, Masur H, Kottilil S.
Lancet Infect Dis. 2015 Sep;15(9):1049-54. doi: 10.1016/S1473-3099(15)00157-7. Epub 2015 Jul 14.
PMID: 26187031

Ledipasvir-sofosbuvir for hepatitis C genotype 4 infection.
Smith MA, Mohammad RA.
Lancet Infect Dis. 2015 Sep;15(9):993-5. doi: 10.1016/S1473-3099(15)00223-6. Epub 2015 Jul 14.
PMID: 26187029